CATEGORY

Immune & Antimicrobial

Immune peptides sit in an awkward spot. Thymosin Alpha-1 is approved in over 30 countries and has more than 100 registered clinical trials, but it is not approved in the US. LL-37 and KPV are preclinical compounds that biohackers have adopted for self-directed immune support despite having no human clinical data. The gap between international clinical use and US regulatory status defines this category.

Stronger evidence in this category

Human trial or approved-indication records are available. Read each page for the exact scope and limits.

Evidence gaps

Public attention is ahead of the current human evidence or regulatory record.

Regulatory Risk

High. None of these are FDA-approved for any indication. Thymosin Alpha-1 has FDA Fast Track designation for certain oncology indications but no US approval. LL-37 has no approved therapeutic products anywhere. KPV has no human clinical trials at all. All are on the FDA bulk substance risk list or under active FDA review.

ALL COMPOUNDS

KPV editorial research scene

KPV

KPV is a three-amino-acid fragment derived from alpha-melanocyte-stimulating hormone. Anti-inflammatory findings come from laboratory and an...

LL-37 editorial research scene

LL-37

LL-37 is the only human cathelicidin antimicrobial peptide and plays several roles in innate immunity. Laboratory research documents antimic...

Thymosin Alpha-1 editorial research scene

Thymosin Alpha-1

Thymosin alpha-1 is an immune-modulating peptide marketed as Zadaxin in several countries. It has been studied across infectious-disease and...