HGH FRAGMENT PEPTIDE (LIPOLYTIC)
AOD-9604
AOD-9604 is a synthetic fragment of human growth hormone developed as a weight-loss candidate. Its Phase 2 obesity program did not meet the ...
CATEGORY
Growth Hormone Secretagogues
The GH secretagogue market includes unapproved compounds, discontinued drug programs, and telehealth compounding. Tesamorelin is the only FDA-approved peptide in this category. The others were abandoned by their original developers, never submitted for approval, or supported by a single pharmacokinetic study that is now being stretched into treatment protocols.
Stronger evidence in this category
Human trial or approved-indication records are available. Read each page for the exact scope and limits.
Evidence gaps
Public attention is ahead of the current human evidence or regulatory record.
Regulatory Risk
High. Tesamorelin (Egrifta) is the only FDA-approved peptide in this category: and only for HIV-associated lipodystrophy, not general use. CJC-1295 was discontinued by ConjuChem and never submitted for approval. MK-677 was discontinued by Merck. Sermorelin's brand product (Geref) was discontinued by the manufacturer. Ipamorelin has no FDA approval record. All are on the FDA bulk substance risk list, and the FDA has issued warning letters to suppliers.
ALL COMPOUNDS
GROWTH HORMONE-RELEASING HORMONE (GHRH) ANALOG PEPTIDE
CJC-1295 (no DAC)
CJC-1295 without DAC (Mod GRF 1-29) is a tetrasubstituted GHRH 1-29 analog with a half-life of approximately 30 minutes. Unlike the DAC form...
GROWTH HORMONE-RELEASING HORMONE (GHRH) ANALOG PEPTIDE
CJC-1295 (with DAC)
CJC-1295 with DAC is a synthetic GHRH analog developed by ConjuChem using drug affinity complex (DAC) technology to bind albumin and extend ...
GROWTH HORMONE SECRETAGOGUE (GHS) PEPTIDE
Ipamorelin
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) that stimulates GH release via ghrelin receptor agonism. It is not ...
ORAL GROWTH HORMONE SECRETAGOGUE (GHS): NON-PEPTIDE
MK-677 (Ibutamoren)
MK-677 (ibutamoren) is a non-peptide, orally active growth hormone secretagogue developed by Merck that mimics ghrelin to stimulate GH and I...
GROWTH HORMONE-RELEASING HORMONE (GHRH) ANALOG PEPTIDE
Sermorelin
Sermorelin is a synthetic N-terminal fragment (1-29) of growth hormone-releasing hormone (GHRH) that was formerly FDA-approved as Geref for ...
GROWTH HORMONE-RELEASING HORMONE (GHRH) ANALOG: FDA-APPROVED (EGRIFTA)
Tesamorelin
Tesamorelin (brand name Egrifta) is an FDA-approved growth hormone-releasing hormone (GHRH) analog indicated for the reduction of excess vis...