PEPTIDEREPORT

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NNMT Inhibitors and Metabolic Research: What the Evidence Shows

Educational review of NNMT inhibitor mechanism and preclinical evidence, relevant to growing search interest in 5-Amino-1MQ.

Peptide Academy channel18:45 runtimenot shown views when checked

Published Jul 20, 2026. Metadata checked Aug 2, 2026.

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Transcript review

3 material claims logged

Published with source gaps audit stateauto-captioned transcript0 operational-guidance flags0 source gaps

Reviewed Aug 2, 2026. Next review Sep 2, 2026.

Educational review of NNMT inhibitor mechanism. Accurately notes that all evidence is preclinical and no human trials exist.

Claim-by-claim audit

What the video says, and what needs checking

00:03:12
Evidence scope

NNMT inhibitors like 5-Amino-1MQ have shown metabolic effects in rodent studies but no human trials have been completed.

Review topic: 5-Amino-1MQ / preclinical evidence.

Checked against: Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice., Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction.

Consistent with published rodent studies (PMID 29155147, PMID 39161060). No human trial data exists.

00:08:45
High-risk evidence claim

No ClinicalTrials.gov records exist for 5-Amino-1MQ as of the video publication date.

Review topic: 5-Amino-1MQ / clinical trial registry.

Checked against: ClinicalTrials.gov exact-name search, accessed 2026-07-12

Verified via ClinicalTrials.gov API search on August 1, 2026. Zero exact-name records found.

Connected research

Compounds discussed

5-Amino-1MQ 5-Amino-1MQ is a small-molecule NNMT inhibitor with published efficacy findings limited to cell and rodent studies. No exact-name ClinicalTrials.gov record was located at the August 1, 2026 research cutoff, and this review did not establish human benefits, safety, pharmacokinetics, or a clinical formulation. FDA has specifically identified 5-Amino-1MQ as ineligible for 503B bulk-compounding exemptions.

Source check

Records used in this claim audit

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

National Library of Medicine · Peer reviewed · 2018 · accessed Jul 12, 2026

Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. doi:10.1016/j.bcp.2017.11.007. PMID 29155147; PMCID PMC5826726.

2 linked pagesOpen original · research-amq-01