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Retatrutide Masterclass: How To Use It Optimally (Dose, Frequency, Diet, Exercise, & Supplements)

Long-form doctor-led retatrutide discussion with monitoring, diet, exercise, and supplement chapters that may shape reader search behavior.

Quinn Stillson MD channel1:14:50 runtime13K views when checked

Published Jun 26, 2026. Metadata checked Jun 30, 2026.

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Connected research

Compounds discussed

Retatrutide Retatrutide is an investigational triple-agonist peptide (GLP-1, GIP, and glucagon receptor agonist) developed by Eli Lilly that showed significant weight loss in Phase 2 clinical trials. It is not FDA-approved for any indication. The peptide has received high online attention from biohacking and fitness communities, requiring careful separation of clinical trial data from social media claims.

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Primary and peer-reviewed records

Retatrutide for Obesity: A Phase 2 Trial

New England Journal of Medicine · Peer reviewed · 2023-06-26 · accessed 2026-07-01

Phase 2 randomized trial of retatrutide (LY3437943), a triple GLP-1/GIP/glucagon receptor agonist, showing dose-dependent weight loss up to 17.5% at 48 weeks in adults with obesity.

TRIUMPH Phase 3 Trial Program for Retatrutide: ClinicalTrials.gov

ClinicalTrials.gov / U.S. National Library of Medicine · Primary regulatory · 2023-07-01 · accessed 2026-07-01

ClinicalTrials.gov registry entry for the TRIUMPH Phase 3 trial program evaluating retatrutide for obesity, sponsored by Eli Lilly. Retatrutide is not FDA-approved for any indication.