PEPTIDE PREPARATION
Cerebrolysin
Cerebrolysin is a porcine brain-derived peptide preparation used for neurological indications in several countries. It is not FDA-approved i...
CATEGORY
Cognitive & Nootropic
This category includes compounds developed in several regulatory systems, with uneven clinical evidence and limited independent replication. Cerebrolysin has human clinical records. Dihexa remains preclinical. Semax, Selank, and Noopept require country-specific regulatory context.
Stronger evidence in this category
Human trial or approved-indication records are available. Read each page for the exact scope and limits.
Regulatory Risk
High. None of these are FDA-approved. Cerebrolysin is approved in 40+ countries but cannot be legally prescribed or sold in the United States. Semax and Selank are on the FDA bulk substance risk list. Noopept is sold as a dietary supplement despite being a registered pharmaceutical in Russia. Dihexa has no human safety or efficacy data whatsoever.
ALL COMPOUNDS
ANGIOTENSIN IV ANALOG / HEPATOCYTE GROWTH FACTOR ACTIVATOR (COGNITIVE ENHANCEMENT)
Dihexa
Dihexa is an angiotensin IV analog studied for effects on the HGF/c-Met signaling system and synapse formation. The reviewed evidence comes ...
SMALL MOLECULE
Methylene Blue
Methylene blue is an FDA-approved prescription treatment for acquired methemoglobinemia. Cognitive and mitochondrial claims discussed online...
DIPEPTIDE NOOTROPIC / N-PHENYLACETYL-L-PROLYLGLYCINE ETHYL ESTER (COGNITIVE ENHANCEMENT)
Noopept
Noopept is a synthetic nootropic registered as a medicine in Russia for forms of cognitive impairment. The clinical record consists largely ...
SYNTHETIC HEPTAPEPTIDE / TUFTSIN ANALOG (COGNITIVE & ANXIOLYTIC)
Selank
Selank is a synthetic tuftsin analog developed and registered as a medicine in Russia. Its evidence base is dominated by Russian-language pr...
RESEARCH PEPTIDE
Semax
Semax is a synthetic ACTH-derived peptide registered as a medicine in Russia. Cognitive and attention claims rely mainly on Russian-language...
LONGEVITY SUPPLEMENT
Spermidine
Spermidine is a naturally occurring dietary polyamine involved in cellular processes including autophagy. Animal studies support geroscience...