RESEARCH PEPTIDE
Epitalon
Epitalon is a synthetic tetrapeptide promoted for longevity and telomere-related effects. The reviewed evidence rests largely on cell studie...
CATEGORY
Longevity & Anti-Aging
Longevity research includes approved drugs studied outside their approved indications, dietary supplements, and experimental compounds. Rapamycin has replicated mouse lifespan findings, but human longevity remains unproven. This page keeps lifespan, healthspan, and biomarker evidence separate.
Stronger evidence in this category
Human trial or approved-indication records are available. Read each page for the exact scope and limits.
Evidence gaps
Public attention is ahead of the current human evidence or regulatory record.
Regulatory Risk
Moderate, with outliers. Rapamycin and metformin are FDA-approved for other indications; off-label longevity use is legal but unproven. NMN is in FDA regulatory limbo under a DSHEA exclusion determination. MOTS-c and Epitalon are on the FDA bulk substance risk list. Spermidine and fisetin are dietary supplements with no drug approval.
ALL COMPOUNDS
SENOLYTIC COMPOUND
Fisetin
Fisetin is a flavonoid found in several fruits and vegetables and studied as a possible senolytic compound. Animal and laboratory findings h...
GROWTH HORMONE SECRETAGOGUE (GHS) PEPTIDE
Ipamorelin
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) that stimulates GH release via ghrelin receptor agonism. It is not ...
LONGEVITY SMALL MOLECULE
Metformin
Metformin is an FDA-approved medicine for type 2 diabetes. Longevity interest comes from biological mechanisms, observational studies, and t...
SMALL MOLECULE
Methylene Blue
Methylene blue is an FDA-approved prescription treatment for acquired methemoglobinemia. Cognitive and mitochondrial claims discussed online...
ORAL GROWTH HORMONE SECRETAGOGUE (GHS): NON-PEPTIDE
MK-677 (Ibutamoren)
MK-677 (ibutamoren) is a non-peptide, orally active growth hormone secretagogue developed by Merck that mimics ghrelin to stimulate GH and I...
MITOCHONDRIAL PEPTIDE
MOTS-c
MOTS-c is a mitochondrial-derived peptide studied in metabolism, exercise, and aging research. Mouse experiments reported metabolic effects,...
LONGEVITY SUPPLEMENT
NAD+ / NMN / NR
NAD+ is an essential cellular coenzyme, while NR and NMN are precursors marketed for healthy-aging claims. Human studies show that these pre...
MACROLIDE MTOR INHIBITOR AND PRESCRIPTION IMMUNOSUPPRESSANT; NOT A PEPTIDE
Rapamycin (sirolimus)
Rapamycin extends lifespan in mice, but human longevity claims remain unproven. Exploratory human trials have measured safety and healthspan...
GROWTH HORMONE-RELEASING HORMONE (GHRH) ANALOG PEPTIDE
Sermorelin
Sermorelin is a synthetic N-terminal fragment (1-29) of growth hormone-releasing hormone (GHRH) that was formerly FDA-approved as Geref for ...
LONGEVITY SUPPLEMENT
Spermidine
Spermidine is a naturally occurring dietary polyamine involved in cellular processes including autophagy. Animal studies support geroscience...