CATEGORY
This category includes approved drugs studied outside their approved indications and experimental small molecules with preclinical evidence only. Methylene blue and metformin have approved uses. 5-Amino-1MQ has rodent findings and no exact-name ClinicalTrials.gov record as of July 12, 2026.
Human trial or approved-indication records are available. Read each page for the exact scope and limits.
Public attention is ahead of the current human evidence or regulatory record.
Low for metformin (FDA-approved, decades of safety data). Moderate for methylene blue (FDA-approved for methemoglobinemia, but cognitive enhancement use is off-label and non-pharmaceutical products raise purity concerns). High for 5-Amino-1MQ: no human clinical trials, not FDA-approved, sold only as a research chemical with zero human safety data.
ALL COMPOUNDS
SMALL-MOLECULE METHYLQUINOLINIUM INHIBITOR OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT); NOT A PEPTIDE
5-Amino-1MQ is a small-molecule NNMT inhibitor with published efficacy findings limited to cell and rodent studies. No exact-name ClinicalTr...
SENOLYTIC COMPOUND
Fisetin is a flavonoid found in several fruits and vegetables and studied as a possible senolytic compound. Animal and laboratory findings h...
LONGEVITY SMALL MOLECULE
Metformin is an FDA-approved medicine for type 2 diabetes. Longevity interest comes from biological mechanisms, observational studies, and t...
SMALL MOLECULE
Methylene blue is an FDA-approved prescription treatment for acquired methemoglobinemia. Cognitive and mitochondrial claims discussed online...
LONGEVITY SUPPLEMENT
NAD+ is an essential cellular coenzyme, while NR and NMN are precursors marketed for healthy-aging claims. Human studies show that these pre...
LONGEVITY SUPPLEMENT
Spermidine is a naturally occurring dietary polyamine involved in cellular processes including autophagy. Animal studies support geroscience...